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Canada Pharmacy: Generic Sildenafil Citrate / Generic Viagra
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Sildenafil Citrate (Viagra) effects erectile function by selectively inhibiting phosphodiesterase type 5, the enzyme responsible for degradation of cGMP in the corpora cavernosa. This enhances the effect of endogenous nitric oxide, producing penile smooth muscle relaxation, arterial dilation and inflow of blood, leading to penile engorgement. Sildenafil (Viagra) does not enhance libido or normal erectile function and rarely produces erections in the absence of sexual stimulation.
The manufacturer's recommended treatment dose is 50 to 100 mg, taken 30 to 60 minutes prior to desired sexual activity. Sildenafil Citrate (Viagra) was approved for use in the treatment of ED by the U.S. Food and Drug Administration. Normal erectile function relies on the coordination of psychological, neurological, endocrine, vascular and muscular factors. Therefore, problems with any one of these elements--secondary to medical or psychiatric illness, psychogenic stress, or a drug side effect--may contribute to ED. Most cases of ED are thought to be multifactorial. Erectile dysfunction (ED) is defined as the persistent "inability to achieve or maintain an erection sufficient for satisfactory sexual performance". While ED is not a life-threatening condition, it may result in withdrawal from sexual intimacy and has been associated with a significant reduction in quality of life. Though estimates of Sildenafil Citrate the prevalence of ED vary depending on the criteria used for diagnosis and the population surveyed, up to 30 million men in the United States may be affected. Sildenafil Citrate |
